L- Asparaginase Injection 5000 & 10,000 KU

Before treatment is started a test dose of 1 to 10 KU of L-Asparaginase in 0.1 ml of distilled water should be injected subcutaneously and the injection site observed for several hours of evidence of primary hypersensitivity.

Side Effects: Nausea, stomach upset, skin rash, acute toxicity.

The main side effect is an allergic or hypersensitivity reaction; anaphylaxis is a possibility.Asparaginase has also been associated with pancreatitis. Additionally, it can also be associated with a coagulopathy as it decreases protein synthesis, including synthesis of coagulation factors (eg progressive isolated decrease of fibrinogen) and anticoagulant factor (generally antithrombin III; sometimes protein C & S as well), leading to bleeding or thrombotic events such as stroke.