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DESCRIPTION

Pemetrexed Injection 500 mg is used for the treatment of malignant pleural mesothelioma in patients whose disease is unresectable or who are otherwise not candidates for curative surgery (In combination with cisplatin); as a single agent for the initial treatment of locally advanced or metastatic non-small cell lung cancer after prior chemotherapy; in combination with cisplatin for the treatment of locally advanced or metastatic nonsquamous non-small cell lung cancer; for the maintenance treatment of patients with locally advanced or metastatic nonsquamous non-small cell lung cancer whose disease has not progressed after 4 cycles of platinum-based first-line chemotherapy.

Mehan Biosciences is Supplier,Exporter ,Wholesaler for Pemetrexed Injection 500 mg in India.

We even offer contract manufacturing services from WHO GMP approved factories.

ADDITIONAL INFORMATION

IV Recommended dose is 500 mg/m ² infused over 10 min on day 1 of each 21-day cycle.

SIDE EFFECTS

Cardiovascular

Supraventricular arrhythmia (less than 1%).

CNS

Fatigue (34%); sensory neuropathy (9%); motor neuropathy (1% to 5%).

Dermatologic

Rash/desquamation (14%); pruritus (7%); alopecia (6%); erythema multiforme (1% to 5%).

EENT

Increased lacrimation, ocular surface disease including conjunctivitis (1% to 5%).

GI

Nausea (31%); anorexia (22%); vomiting (16%); stomatitis/pharyngitis (15%); diarrhea (13%); mucositis/stomatitis (7%); constipation (6%); abdominal pain (1% to 5%); colitis (postmarketing).

Genitourinary

CrCl decreased, creatinine increased, glomerular filtration rate decreased (1% to 5%); renal failure (less than 1%).

Hematologic-Lymphatic

Anemia (19%); leukopenia (12%); neutropenia (11%); thrombocytopenia (8%); febrile neutropenia (1% to 5%).

Hepatic

Increased ALT (10%); increased AST (8%).

Hypersensitivity

Allergic reactions/hypersensitivity (1% to 5%).

Respiratory

Interstitial pneumonitis (postmarketing).

Miscellaneous

Fever (8%); infection (5%); edema (1% to 5%); radiation recall (postmarketing).

Pemetrexed Injection 500 mg